Visual Function and Foveal Avascular Zone Changes in Patients with Diabetic Macular Edema After Intravitreal Injection of Ranibizumab

Document Type : Original Articles

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Mansoura Ophthalmic Center, Mansoura University

Abstract

Purpose: to assess changes in FAZ area in patients with diabetic macular edema(DME) after intravitreal injection (IVI) of anti-VEGF (Ranibizumab) and its effect on visual function.
Methods: Patients with DME were subjected preoperative to the following ophthalmologic examination: Best corrected visual acuity (BCVA), Contrast sensitivity test, Color vision test, slit lamp examination, fundus examination, ocular tension, FAZ area by Optical Coherence Tomography Angiography (OCTA). Then all patients were injected intravitreally with Anti-VEGF (Ranibizumab) 3 doses with one month interval. Postoperative data was collected regarding the (BCVA), contrast sensitivity test, color vision test, slit lamp examination, fundus examination, ocular tension, FAZ evaluation by OCTA.
Results: The study included 30 eyes with DME, the mean age was 57.4± 6.9 years, 19 (63.33%) were females, and only 11 (36.33%) were males. all visual functions significantly improved after intravitreal Ranibizumab administration. Also, there was correlation between visual acuity and FAZ shape, according to FAZ shape pre-operative, all cases had more irregular shape with mean BCVA 0.9746±0.28. while post-operative, 27 (90%) patients had more regular FAZ shape with mean BCVA 0.413±0.162 and only 3 (10%) patients had irregular FAZ shape with mean BCVA 0.852±0.128.
Conclusion: Assessing both the size and shape of FAZ is probably important for detecting pathological alteration of the macula and prediction of visual outcomes in DR, there was significant improvement in visual functions as expected.

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Egyptian Journal of Ophthalmology
Volume 4, Issue 3
September 2024
Pages 168-180

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