Evaluation of Mycophenolate Mofetil role as an immunomodulator in high risk keratoplasty patients

Document Type : Original Articles

Authors

1 Mansoura University, Faculty of Medicine

2 Mansoura Ophthalmic Center, Mansoura University

10.21608/ejomos.2024.321628.1146

Abstract

Objectives: This study is conducted to evaluate the role of Mycophenolate Mofetil in reduction of corneal graft rejection rates in high risk keratoplasty patients.
Patients and Methods: Study includes 50 eyes scheduled for penetrating keratoplasty who met the inclusion criteria of high risk keratoplasty. Patients will be randomly divided into two groups; MMF group (25 patients) will receive MMF as an immunosuppressive drug pre and postoperative in addition to the topical steroid and antibiotic eye drops postoperative. Corticosteroid group (25 patients) will receive systemic corticosteroid pre and postoperative in addition to topical steroid and antibiotic eye drops postoperative.
Results: Statistically significant differences were recorded in terms of BCVA after 1st week, 1st month, 3rd month, 6th month and one year of follow up in each group of studied groups. Statistically significant differences were documented according to complications of treatment after keratoplasty, state of corneal grafts and number of rejection episodes between studied groups (P<0.001).
Conclusion: Mycophenolate Mofetil has a significant role in decreasing rates of corneal graft rejection after high risk penetrating keratoplasty.

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Egyptian Journal of Ophthalmology
Volume 5, Issue 3
September 2025
Pages 122-133

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