Evaluation of tear film before and after corneal collagen crosslinking in patients with keratoconus

Hefnawy, Abdelrahman; El-Khair, Sami Ali Abou; Hashish, Aya Mohamed; Gaafar, Walid

doi:10.21608/ejomos.2024.327834.1153

Evaluation of tear film before and after corneal collagen crosslinking in patients with keratoconus

Document Type : Original Articles

Authors

¹ Mansoura Ophthalmic Center, Mansoura University

² Department of Ophthalmology, Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt

10.21608/ejomos.2024.327834.1153

Abstract

Purpose: This study was done to evaluate tear film changes before and after corneal collagen cross-linking in patients with keratoconus.
Patients and methods: The study included 60eyes of 30keratoconus patients who underwent CXL surgery at Mansoura Ophthalmic Center. The patients evaluation includes history, refraction, slit-lamp examination, fundoscopy, and IOP measurement. The Pentacam was utilized to diagnose and assess the progression of keratoconus. The Media Works Dry Eye Diagnostic System (D130)was utilized to evaluate eight tear film parameters before and after the surgery. The outcome measures were non-invasive break-up time (NIBUT),Hybrid break-up time (H-BUT),tear meniscus height, lipid layer, eyelid edge, meibomian gland, ocular surface staining, and eye redness analysis.
Results: The study group mean age was 22.03years. There was a slight improvement in UCVA from preoperative to 6th month follow-up, but no statistical significance difference. BCVA remained the same from preoperative to 6th month follow-up. Preoperatively, 52eyes (86.7%)can be refracted, increasing to 56eyes (93.3%)at 6th month follow-up. Cylinder amount decreased from preoperative to 6th month, but no statistically significant difference. Keratometry showed a reduction in mean values of K1, K2, and Kmax. Corneal thickness decreased slightly in the thinnest location, but no significant difference. There was a statistically significant improvement in NIBUT and H-BUT 1st rupture time and average rupture time, and a significant improvement in their grades by the end of follow-up.
Conclusion: The study demonstrates that epi-off CXL treatment can control keratoconus progression and improve tear film parameter, reducing dry eye symptoms within 6months in patients with the keratoconus.

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